GeaNUS Technology

Hands-on Workshop on Pelletization, Pellet Coating and MUPS Tableting

Workshop Programme

Schedule: Theory & Practice

29 – 31 October: 0900 – 1800 hr

1 November: 0900 – 1300 hr

Objective

From this workshop, participants will gain useful insights and knowledge from the updated comprehensive overview of making pellets by extrusion-spheronization. Pellets containing a drug can be coated by fluidized bed coating for controlled release.

Alternatively, drug layering onto nonpareils followed by sustained layer overcoating can prolong drug release. The design of multi-unit pellet system (MUPS) tablets will be demonstrated. Through concise lectures by experts and hands-on practicals, important skills would be imparted to the participants. Participants will also be taught methods to prepare and process pellets into useful multi-particulate dosage forms. Accompanying lectures will provide an in-depth understanding of the design of multi-particulate delivery systems.

Theory

  • Particle layering
  • Science of spheroid formation
  • Extrusion-spheronization: Production of pellets
  • Extrusion-spheronization:
  • Scale-up
  • Precision Coater system including scale-up
  • Flexstream® coating system including scale-up
  • Functionality of the pelletization aid
  • Cushioning agents for MUPS tableting
  • Characterization of pellets and MUPS tabletsMUPS tablets – Design and challenges

Practice

  • Producing particulates by spray drying
  • Practical on extrusion-spheronization
  • Pellet coating using the Precision Coater
  • Practice in drug layering and coating by FlexStream
  • Compaction using a compaction simulator
  • Preparation of MUPS tablets

Others

  • Course materials will be supplied.
  • Daily lunches and teas will be provided.
  • Limited class size, registration subjected to availability &
    on a first-come-first-served basis.
  • Workshop will be in English and Chinese translations will
    be provided.

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